Rupture of multiple catch-slip bonds: Two-state two-pathway catch-slip bonds
University of Maryland Baltimore County, 21250, Baltimore, Maryland, USA
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Accepted: 29 October 2013
Published online: 26 November 2013
We performed Monte Carlo simulation of the detachment of a polymorphonuclear (PMN) leukocyte immersed in a Newtonian fluid and adhered to a substrate by multiple catch-slip bonds. We found that at certain loading rates the interplay of multiple catch-slip bonds leads to a bimodal distribution of the bond rupture force. We also found that the low force peak in these bond rupture force distributions switches to a high force peak with a gradual increase in the loading rate. These trends in the bond rupture force distributions are characteristics of two-state systems. Consequently, though individual catch-slip bonds follow one-state two-pathway energy landscape, their interplay mimics a two-state two-pathway energy landscape.
Key words: Soft Matter: Colloids and Nanoparticles
© EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg, 2013