Theoretical model for cell migration with gradient sensing and shape deformation
Center for Developmental Biology, RIKEN, Chuo-ku, Kobe, 565-0871, Hyogo, Japan
29846 Japan Science and Technology Agency, CREST, 1-3 Yamadaoka, Suita, Osaka, Japan
Accepted: 11 March 2013
Published online: 11 April 2013
Amoeboid cells take various shapes during migration, depending on the cell type and its environment. Deformability of the cell shape can then affect the migrating behavior. In this article, we introduce a theoretical model of chemotactic cell migration with elliptical shape deformation. Based on the model, we calculate the stationary distributions of the migration directions analytically. As a result, we find that the distributions show different characteristics depending on the difference in the interdependence of the internal polarity, cell morphology and gradient sensing.
Key words: Living systems: Cellular Processes
© EDP Sciences, SIF, Springer-Verlag Berlin Heidelberg, 2013