https://doi.org/10.1140/epje/s10189-024-00416-9
Regular Article - Soft Matter
Quantitative comparison of cell–cell detachment force in different experimental setups
1
Max Planck Institute for the Physics of Complex Systems, 01187, Dresden, Germany
2
Laboratoire Physico Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168, 75005, Paris, France
Received:
3
November
2023
Accepted:
12
March
2024
Published online:
2
April
2024
We compare three different setups for measuring cell–cell adhesion. We show that the measured strength depends on the type of setup that is used. For identical cells different assays measure different detachment forces. This can be understood from the fact that cell–cell detachment is a global property of the system. We also analyse the role of external force and line tension on contact angle and cell–cell detachment. Comparison with the experiments suggest that viscous forces play an important role in the process. We dedicate this article to Fyl Pincus who for many of us is an example to be followed not only for outstanding science but also for a marvelous human behavior.
© The Author(s) 2024
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