https://doi.org/10.1140/epje/s10189-023-00389-1
Regular Article - Flowing Matter
Observation of non-equilibrium fluctuation in the shear-stress-driven hemoglobin aggregates
1
Nanostructure and Soft Matter Physics Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, 752050, Jatni, Bhubaneswar, India
2
Statistical Mechanics Laboratory, School of Basic Sciences, Indian Institute of Technology Bhubaneswar, 752050, Jatni, Bhubaneswar, India
Received:
12
June
2023
Accepted:
27
November
2023
Published online:
20
December
2023
Non-equilibrium fluctuations caused by the rearrangement of hemoglobin molecules into an aggregate state under shear stress have been investigated experimentally. The flow response under the shear stress (σ) corroborates the presence of contrasting aggregate and rejuvenation states governed by entropy production and consumption events. From the time-dependent shear rate fluctuation studies of aggregate states, the probability distribution function (PDF) of the rate of work done is observed to be spread from negative to positive values with a net positive mean. The PDFs follow the steady-state fluctuation theorem, even at a smaller timescale than that desired by the theorem. The behavior of the effective temperature (Teff) that emerges from a non-equilibrium fluctuation and interconnects with the structural restrictions of the aggregate state of our driven system is observed to be within the boundary of the thermodynamic uncertainty. The increase in Teff with the applied σ illustrates a phenomenal nonlinear power flux-dependent aggregating behavior in a classic bio-molecular-driven system.
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© The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
