Regular Article - Living Systems
Accuracy in readout of glutamate concentrations by neuronal cells
Indian Institute of Technology Goa At Goa College of Engineering Campus, Ponda-403401, Farmagudi, Goa, India
Accepted: 28 March 2023
Published online: 19 April 2023
Glutamate and glycine are important neurotransmitters in the brain. An action potential propagating in the terminal of a presynaptic neuron causes the release of glutamate and glycine in the synapse by vesicles fusing with the cell membrane, which then activate various receptors on the cell membrane of the post-synaptic neuron. Entry of Ca through the activated NMDA receptors leads to a host of cellular processes of which long-term potentiation is of crucial importance because it is widely considered to be one of the major mechanisms behind learning and memory. By analysing the readout of glutamate concentration by the post-synaptic neurons during Ca signaling, we find that the average receptor density in hippocampal neurons has evolved to allow for accurate measurement of the glutamate concentration in the synaptic cleft.
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