https://doi.org/10.1140/epje/s10189-021-00149-z
Regular Article - Living Systems
Activity-induced instabilities of brain organoids
1
Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Rd, CB2 1EW, Cambridge, UK
2
Department of Applied physics, Eindhoven University of Technology, Eindhoven, The Netherlands
3
The Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark
a
kt500@cam.ac.uk
c
doostmohammadi@nbi.ku.dk
Received:
6
August
2021
Accepted:
15
November
2021
Published online:
7
December
2021
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
© The Author(s) 2021
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