Mode of lysozyme protein adsorption at end-tethered polyethylene oxide brushes on gold surfaces determined by neutron reflectivity

Warren Taylor; Stephen Ebbens; Maximillian W. A. Skoda; John R. P. Webster; Richard A. L. Jones

doi:10.1140/epje/i2015-15014-7

EPJ

Mode of lysozyme protein adsorption at end-tethered polyethylene oxide brushes on gold surfaces determined by neutron reflectivity

Warren Taylor¹^*, Stephen Ebbens¹, Maximillian W. A. Skoda², John R. P. Webster² and Richard A. L. Jones¹

¹ Physics and Astronomy Department, University of Sheffield, Sheffield, UK
² Rutherton Appleton Laboratory, ISIS, Oxfordshire, UK

Received: 19 January 2014
Revised: 20 August 2014
Accepted: 3 February 2015
Published online: 9 March 2015

Abstract

The mode of lysozyme protein adsorption at end-tethered thiol-terminated polyethylene oxide brushes grafted upon gold was determined in situ by neutron reflectivity using the INTER instrument at target station 2, ISIS, RAL, UK. It was found that the most probable position of protein adsorption at these weakly protein resistive brushes was at the gold-brush interface in the so-called primary protein position.

Key words: Soft Matter: Polymers and Polyelectrolytes

23rd International Summer School on Vacuum, Electron, and Ion Technologies (VEIT)
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EPJ

Mode of lysozyme protein adsorption at end-tethered polyethylene oxide brushes on gold surfaces determined by neutron reflectivity

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