Eur. Phys. J. E (2011) 34: 123
https://doi.org/10.1140/epje/i2011-11123-7

Molecular properties of hybrid macromolecular antioxidants: Dextran hydrophobically modified by sterically hindered phenols

¹ Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, v.v.i. Heyrovsky Sq. 2, 162 06, Prague 6, Czech Republic
² V.A. Fock Institute of Physics, St. Petersburg State University, Uljanovskaja ul.1, 198504, St. Petersburg, Russia
³ Helmholz-Zentrum Geesthacht: Zentrum für Material- und Küstenforschung GmbH, DE-21502, Geesthacht, Germany
⁴ Chemical Faculty, St. Petersburg State University, University av. 26, 198504, Saint-Petersburg, Russia

^* e-mail: filippov@imc.cas.cz

Received: 19 July 2011
Accepted: 25 October 2011
Published online: 23 November 2011

Abstract

The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity —polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure.