Chromatin fiber functional organization: Some plausible models
Laboratoire de Physique Théorique de la Matière Condensée, Université Pierre et Marie Curie, 4 Place Jussieu, Case courrier 121, 75252, Paris Cedex 05, France
2 IHÉS (Institut des Hautes Études Scientifiques), Le Bois-Marie, 35 route de Chartres, 91440, Bures-sur-Yvette, France
Accepted: 3 January 2006
Published online: 23 February 2006
We here present a modeling study of the chromatin fiber functional organization. Multi-scale modeling is required to unravel the complex interplay between the fiber and the DNA levels. It suggests plausible scenarios, including both physical and biological aspects, for fiber condensation, its targeted decompaction, and transcription regulation. We conclude that a major role of the chromatin fiber structure might be to endow DNA with allosteric potentialities and to control DNA transactions by an epigenetic tuning of its mechanical and topological constraints.
PACS: 87.16.Sr Chromosomes, histones – / 87.15.He Dynamics and conformational changes –
© EDP Sciences, Società Italiana di Fisica and Springer-Verlag, 2006