Eur. Phys. J. E 7, 393-396 (2002)
DOI: 10.1140/epje/i2001-10100-1
Solute effects on the helix-coil transition
O. Farago and P. PincusMaterials Research Laboratory, University of California, Santa Barbara, CA 93106, USA farago@mrl.ucsb.edu
fyl@mrl.ucsb.edu
(Received 10 December 2001 and Received in final form 22 March 2002)
Abstract
We discuss the effects of the solvent composition on the helix-coil
transition of a polypeptide chain. We use a simple model to
demonstrate that improving the hydrogen-bonding ability of the
solvent can make the transition less cooperative, without affecting
the transition temperature. This effect is very different from other
solvent effects which primarily influence the melting transition
rather than the cooperativity.
87.15.-v - Biomolecules: structure and physical properties.
05.70.Fh - Phase transitions: general studies.
61.41.+e - Polymers, elastomers, and plastics.
© EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2002