https://doi.org/10.1140/epje/s10189-026-00564-0
Research – Living Systems
Geometric confinement reveals scale-free velocity correlations in epithelial cell monolayer
1
Université Claude Bernard - Lyon 1, CNRS, ILM, UMR5306, 69100, Villeurbanne, France
2
Université Paris Cité, CNRS, MSC, UMR7057, 75006, Paris, France
a
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Received:
31
July
2025
Accepted:
26
January
2026
Published online:
26
February
2026
Abstract
Collective cell flows are a hallmark of tissue dynamics in development, wound healing, and various diseases. Here, we investigate how the size, shape, topology and rigidity of patterned substrate influence the organization of flows and mechanical fields in an epithelial MDCK cell monolayer at several time and space scales. Using micropatterned substrates with and without free front (a strip and a closed racetrack), we show that confinement and obstacles induce spatial heterogeneities in velocity and force fields, leading to the emergence of domains, waves, and long-range correlations. We show that spatial velocity correlations are scale-free, following a power law whose exponent evolves as the monolayer matures. This challenges the notion of a single intrinsic correlation length. We also show that in absence of free front, spontaneous collective motions are stronger on soft than on hard substrate. Our findings provide new insights into the rheology of epithelial tissues and the interplay between mechanics and collective migration.
Supplementary Information The online version contains supplementary material available at https://doi.org/10.1140/epje/s10189-026-00564-0.
Copyright comment Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Guillaume Duprez and Mélina Durande have contributed equally to this work.
© The Author(s), under exclusive licence to EDP Sciences, SIF and Springer-Verlag GmbH Germany, part of Springer Nature 2026
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
