2020 Impact factor 1.890
Soft Matter and Biological Physics


Eur. Phys. J. E 5, 485-497 (2001)

Simulation study of lateral diffusion in lipid-sterol bilayer mixtures

J.M. Polson1, I. Vattulainen2, H. Zhu1 and M.J. Zuckermann1, 3

1  Centre for the Physics of Materials, Department of Physics, McGill University, Rutherford Building, 3600 Rue Université, Montréal, PQ, Canada H3A 2T8
2  Department of Chemistry, Building 206, Technical University of Denmark, 2800 Lyngby, Denmark
3  School of Physics, University of New South Wales, Kensington Campus, Old Main Building, Kensington, Sydney 2052, Australia

Ilpo.Vattulainen@csc.fi

(Received 24 November 2000 and Received in final form 30 April 2001)

Abstract
We employ off-lattice Monte Carlo simulations to study lateral diffusion in lipid-sterol bilayers using a two-dimensional model system which has been designed to simulate the experimental phase diagrams of both lipid-cholesterol and lipid-lanosterol systems. We focus on the effects of varying sterol concentration and temperature on the tracer diffusion coefficient, D, which characterizes the lateral motion of single tagged lipids in a bilayer. Generally, we find that increasing the cholesterol concentration suppresses D due to an increased conformational ordering of lipid chains. We argue that this effect competes with an increase in the average free area per lipid, which favours an increase in D. At temperatures close to the main transition temperature, the competition between the two effects leads to intriguing behavior of D. Overall, the model results are in excellent qualitative agreement with available experimental results for lipid-cholesterol mixtures. Additional studies of a model lipid-lanosterol system, for which experimental diffusion results are not available, predict that the presence of lanosterol has a smaller effect than cholesterol on reducing D relative to the pure lipid system. We conclude that the molecular model employed contains the essential features required to describe many of the qualitative features of the lateral diffusion behavior in lipid-sterol systems.

PACS
87.16.Dg - Membranes, bilayers, and vesicles.
87.16.Ac - Theory and modeling; computer simulation.
87.15.Vv - Diffusion.
87.14.Cc - Lipids.


© EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2001